The ITREMA project consists of a pragmatic randomized open-label clinical trial and several research studies and implementation projects linked to the clinical trial. Below is an overview of research output generated in the context of the ITREMA project.
Peer reviewed manuscripts
Clinical impact of pretreatment human immunodeficiency virus drug resistance in people initiating nonnucleoside reverse transcriptase inhibitor-containing antiretroviral therapy: a systematic review and meta-analysis
Point-of-care detection of nonadherence to antiretroviral treatment for HIV-1 in resource-limited settings using drug level testing for Efavirenz, Lopinavir, and Dolutegravir: a validation and pharmacokinetic simulation study Hermans LE, Nijhuis M, Tempelman HA, Houts T, Schuurman R, Burger DM, Wensing AMJ, Ter Heine R. J Acquir Immune Defic Syndr. 2021 Aug 1 https://doi.org/10.1097/qai.0000000000002681
Risk factors for loss to follow-up from antiretroviral therapy programmes in low-income and middle-income countries Frijters EM, Hermans LE, Wensing AMJ, Devillé WLJM, Tempelman HA, De Wit JBF. AIDS. 2020 Jul 15 https://doi.org/10.1097/qad.0000000000002523
Virological suppression and clinical management in response to viremia in South African HIV treatment program: A multicenter cohort study Hermans LE, Carmona S, Nijhuis M, Tempelman HA, Richman DD, Moorhouse M, Grobbee DE, Venter WDF, Wensing AMJ. PLoS Med. 2020 Feb 25 https://doi.org/10.1371/journal.pmed.1003037
Drug level testing as a strategy to determine eligibility for drugresistance testing after failure of ART: a retrospective analysis ofSouth African adult patients on second-line ART Hermans LE, Steegen K, Ter Heine R, Schuurman R, Tempelman HA, Moraba R, van Maarseveen E, Nijhuis M, Pillay T, Legg-E’Silva D, Snyman T, Schapiro JM, Burger DM, Carmona S, Wensing AM. Journal of the International AIDS Society. 2020 June 9 https://doi.org/10.1002/jia2.25501
Effect of HIV-1 low-level viraemia during antiretroviral therapy on treatment outcomes in WHO-guided South African treatment programmes: a multicentre cohort study. Hermans LE, M. Moorhouse, S. Carmona, D.E. Grobbee, L.M. Hofstra, D.D. Richman, H.A. Tempelman, W.D.F. Venter, A.M.J. Wensing. Lancet Infect Dis. 2017 Nov 17. pii: S1473-3099(17)30681-3.
Increased risk of cART failure after low-level viremia under WHO guidelines. Hermans L, Moorhouse M, Carmona S, Grobbee D, Hofstra M, Richman D, Tempelman H, Venter W, Wensing A. Oral presentation at the annual Conference on Retroviruses and Opportunistic Infections (CROI), Seattle WA, USA, 2017.
PI drug level testing as a screening tool for drug resistance in 2nd line ART failure. Hermans LE, Steegen K, ter Heine R, Schuurman R, Tempelman HA, Moraba R, van Maarseveen E, Pillay T, Legg-Esilva D, Schapiro JM, Burger DM, Carmona S, Wensing AMJ. Accepted for mini-oral poster presentation at the annual Conference on Retroviruses and Opportunistic Infections (CROI), Seattle, USA, 2019.
Impact of pretreatment drug resistance on treatment outcome in the ITREMA trial. Hermans LE, Hofstra LM, Schuurman R, ter Heine R, Tempelman HA, Venter WDF, Nijhuis M, Wensing AMJ. Accepted for poster presentation at the annual Conference on Retroviruses and Opportunistic Infections (CROI), Seattle, USA, 2019.
Point-of-care drug level testing for adherence assessment of first and second line antiretroviral treatment in resource-limited settings Hermans LE, Nijhuis M, Kasper KC, O’Malley R, Oh SJ, Schuurman R, Tempelman HA, Venter WDF, Burger DM, Wensing AM, ter Heine R. . Poster presentation at the International AIDS conference, Amsterdam, The Netherlands, 2018.
High rates of viral resuppression on first-line ART after initial virological failure. Hermans L, Tempelman H, Carmona S, Nijhuis M, Grobbee D, Richman D, Moorhouse M, Venter W, Wensing A. Poster presentation at the annual Conference on Retroviruses and Opportunistic Infections (CROI), Boston, USA, 2018.
Drug level screening to determine eligibility for drug resistance testing in South African patients with virological failure of second-line ART using Dried Blood Spots. LE Hermans, HA Tempelman, SR Moraba, R Schuurman, EM van Maarseveen and AMJ Wensing. Oral presentation at the International Workshop on HIV Drug Resistance and Treatment Strategies – IWHDR, Johannesburg, South Africa, 2017.
The ITREMA project is a collaboration between investigators from the University Medical Center Utrecht (UMCU), Utrecht University, Radboud University Medical Center Nijmegen, the University of the Witwatersrand (Johannesburg, South Africa) and Ndlovu Care Group (NCG, Limpopo, South Africa).
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3584 CX Utrecht, The Netherlands
University Medical Centre Utrecht, Department of Medical Microbiology